Mind the Gap: Lack of Association between KIR3DL1*004/HLA‐Bw4–Induced Natural Killer Cell Function and Protection from HIV Infection
نویسندگان
چکیده
منابع مشابه
Increased natural killer cell activity in viremic HIV-1 infection.
NK cells are a subset of granular lymphocytes that are critical in the innate immune response to infection. These cells are capable of killing infected cells and secreting integral cytokines and chemokines. The role that this subset of cytolytic cells plays in HIV infection is not well understood. In this study, we dissected the function of NK cells in viremic and aviremic HIV-1-infected subjec...
متن کاملChanges in Natural Killer Cell Activation and Function during Primary HIV-1 Infection
BACKGROUND Recent reports suggest that Natural Killer (NK) cells may modulate pathogenesis of primary HIV-1 infection. However, HIV dysregulates NK-cell responses. We dissected this bi-directional relationship to understand how HIV impacts NK-cell responses during primary HIV-1 infection. METHODOLOGY/PRINCIPAL FINDINGS Paired samples from 41 high-risk, initially HIV-uninfected CAPRISA004 part...
متن کاملon the relationship between different discourse markers and information-gap and reasoning-gap tasks, and the effectiveness of input enhancement type of instruction on students acquisition of discourse markers.
abstract tasks nowadays are at the center of attention in sla research. task types is one of the critical issues in this regard, their effectiveness and suitability to any particular context, their characteristics and the result they yield are among some of these issues. on the other hand, discourse markers (dms) have been very much investigated and their effectiveness in conveying the meaning...
15 صفحه اولLack of Association between Interleukin-10 Gene Promoter Polymorphisms with HIV Susceptibility and Progression to AIDS
Background & Objective: Interleukin (IL)-10 is an important anti-inflammatory and immunomodulatory cytokine. Some authors believe that single nucleotide polymorphisms (SNP) in the promoter region of the IL-10 gene have been associated with susceptibility to HIV infection and progression to AIDS, but its role is not clearly defined yet. The present study was undertaken to evaluate the a...
متن کاملAltered Natural Killer Cell Function in HIV-Exposed Uninfected Infants
OBJECTIVES HIV-exposed uninfected (HEU) infants have higher rates of severe and fatal infections compared with HIV-unexposed (HUU) infants, likely due to immune perturbations. We hypothesized that alterations in natural killer (NK) cell activity might occur in HEU infants and predispose them to severe infections. DESIGN Case-control study using cryopreserved peripheral blood mononuclear cells...
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ژورنال
عنوان ژورنال: The Journal of Infectious Diseases
سال: 2010
ISSN: 0022-1899,1537-6613
DOI: 10.1086/655966